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Synthesis studies related to compactin and mevinolin: A new synthesis of the hexahydronaphthalene portion of compactin.

โœ Scribed by Paul C. Anderson; Derrick L.J. Clive; Claire F. Evans

Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
235 KB
Volume
24
Category
Article
ISSN
0040-4039

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Synthesis of a chiral synthon for the la
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โœ Bruce D. Roth; W.Howard Roark ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 229 KB

The stereoselective Michael addition of alcohols dihydro-2tj-pyran-2-one afforded high yields of a key chiral portion of compactin and mevinolin. to 6-tosyloxymethyl-5,6synthon for the lactone Compactin (1) mevinolin (2) and related compounds have been cholesterol levels in animal models and man and