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A new route in the sequential total synthesis of compactin

โœ Scribed by N.N. Girotra; N.L. Wendler


Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
132 KB
Volume
24
Category
Article
ISSN
0040-4039

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โœ E.J. Corey; Paul Da Silva Jardine; Tetsuya Mohri ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 217 KB

An enantioselective route for the total synthesis of forskolin, a potent activator of adenylate cyclase, has been developed which is based on reduction of dienone 3 to the (S)-alcohol4 and conversion in two steps to tricyclic lactone 9, obtained in optically pure form simply by recrystallization. A