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An organocatalytic route to the synthesis of lactone moiety of compactin and mevinolin

✍ Scribed by Pradeep Kumar; Menaka Pandey; Priti Gupta; Dilip D. Dhavale

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
259 KB
Volume
51
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES

Synthesis of a chiral synthon for the la
Synthesis of a chiral synthon for the lactone portion of compactin and mevinolin
✍ Bruce D. Roth; W.Howard Roark πŸ“‚ Article πŸ“… 1988 πŸ› Elsevier Science 🌐 French βš– 229 KB

The stereoselective Michael addition of alcohols dihydro-2tj-pyran-2-one afforded high yields of a key chiral portion of compactin and mevinolin. to 6-tosyloxymethyl-5,6synthon for the lactone Compactin (1) mevinolin (2) and related compounds have been cholesterol levels in animal models and man and

A Facile Asymmetric Synthesis of the Com
A Facile Asymmetric Synthesis of the Compactin Lactone Moiety
✍ Schabbert, Silke ;Tiedemann, Ralf ;Schaumann, Ernst πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 227 KB

## Abstract Starting from (__R__)‐__O__‐benzylglycidol and a sulfur‐stabilized allyl anion, a (3 + 3) synthesis of the Ξ±,β‐unsaturated (6__S__)‐δ‐lactone 7 is achieved. Subsequent diastereoselective addition of a phenyldimethylsilyl cuprate and unmasking of the latent hydroxy function provides the

A novel diastereoselective synthesis of
A novel diastereoselective synthesis of the lactone moiety of compactin
✍ Kapa Prasad; Oljan Repič πŸ“‚ Article πŸ“… 1984 πŸ› Elsevier Science 🌐 French βš– 186 KB

A new synthesis of racemic $-hydroxy-&lactone 10 with requisite relative stereochemistry as in compactin (la) is described utilizing cis-cyclohexane-1,3,5-trio1 (2) as the starting material. Compactin' (la) and mevinolin\* -(lb) have attracted a great deal of interest from synthetic organic chemists