Synthesis of [ω-3H-MeBmt1]-cyclosporin A
✍ Scribed by Bohuslav Černý; Alexandr Jegorov; Jana Polívková; Petr Sedmera; Vladimír Havlíček
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- French
- Weight
- 236 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
L-[3,4-'H(N)]-Glutamine was cyclized to ['HI-pyroglutamic acid and coupled with [des-pGlu']-AKH-I to give [3H-pyroglutamy11]-adipokinetic hormone-I with a specific activity of 46 Ci/mmole. Results relating to stability of this product during storage are reported.
12-3H]-(+)-Calanolide A (9) was synthesized in five steps from readily available phloroglucinol (1). Stereoselective Luche reduction of transketone 8 with cerium(ll1) chloride and sodium borotritide in methanol gave 338 pCi of 9 with a specific activity of 63.0 mCi/mmol.