Synthesis of [12-3H]-(±)-calanolide A

✍ Scribed by Ken S. Rehder; Maria K. Hristova-Kazmierski; John A. Kepler

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 216 KB
• Volume: 38
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/(sici)1099-1344(199612)38:12<1077::aid-jlcr930>3.0.co;2-#

✦ Synopsis

12-3H]-(+)-Calanolide A (9) was synthesized in five steps from readily available phloroglucinol (1). Stereoselective Luche reduction of transketone 8 with cerium(ll1) chloride and sodium borotritide in methanol gave 338 pCi of 9 with a specific activity of 63.0 mCi/mmol.