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Synthesis of 3H-tolperisone

✍ Scribed by Axel Dietrich; Gregor Fels


Publisher
John Wiley and Sons
Year
1999
Tongue
French
Weight
244 KB
Volume
42
Category
Article
ISSN
0022-2135

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12-3H]-(+)-Calanolide A (9) was synthesized in five steps from readily available phloroglucinol (1). Stereoselective Luche reduction of transketone 8 with cerium(ll1) chloride and sodium borotritide in methanol gave 338 pCi of 9 with a specific activity of 63.0 mCi/mmol.