Synthesis of 3H and 14C labelled SCH 484
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D. Hesk; C. Bowlen; S. Hendershot; D. Koharski; P. McNamara; D. Rettig; S. Saluj
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Article
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1996
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John Wiley and Sons
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French
β 404 KB
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3H-Sch 47949, racemic 3H-Sch 48461, was prepared at a specific activity of 40 mCi/mmole by Pt catalysed exchange with tritiated water. 3H-Sch 48461 was prepared at a specific activity of 64.6 Ci/mmole by a Pd/C catalysed reduction of an olefinic intermediate. 14C-Sch 48461 was prepared in 8 steps fr