𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of Δ1 and Δ1(6) tetrahydrocannabinol metabolites

✍ Scribed by Z. Ben-Zvi; R. Mechoulam; S.H. Burstein

Book ID
108383178
Publisher
Elsevier Science
Year
1970
Tongue
French
Weight
137 KB
Volume
11
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Hashish : Synthesis of (−)-7-hydroxy-Δ1(
Hashish : Synthesis of (−)-7-hydroxy-Δ1(6)-tetrahydrocannabinol
✍ Klaus K. Weinhardt; Raj K. Razdan; Haldean C. Dalzell 📂 Article 📅 1971 🏛 Elsevier Science 🌐 French ⚖ 142 KB

It is well documented 2,3,4,5 that the primary reaction in the metabolism of A'-and Al(e) -THCs\* (la and 2a) is oxidation to the 7-hydroxy derivatives J& and &.

A biomimetic synthesis of Δ1-tetrahydroc
A biomimetic synthesis of Δ1-tetrahydrocannabinol
✍ T.H. Chan; T. Chaly 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 206 KB

Condensatzon of I,&bzs(trunethylszloxyl-I-methoxybutadiene wzth the aced chloride ;z gave methyl olivetolate (;?I. Condensatzon of 22 wzth (+I-p-mentha-2,8-dzenl-01 gave methyl Al-tetrahydrocannabinolate (14) zn 55% zsolated yzeld. Alkalzne hydrolyses of lg gave Al-tetrahydrocannabznol-72, Al-THCI.

A urinary metabolite of Δ1-tetrahydrocan
A urinary metabolite of Δ1-tetrahydrocannabinol. The first synthesis of 4′′-hydroxy-Δ1-tetrahydrocannabinol-7-oic acid labelled with deuterium
✍ Maria Szirmai; Helena Odqvist; Magnus M. Halldin 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 773 KB

The first synthesis of 4"-hydroxy-A1-THC-7-oic acid, one of the three major metabolites of AI-THC identified in human urine is discussed. Methyl 4-(3,5-dihydroxyphenyl)butanoate (8) was prepared from 3,5-dihydmxybenzoic acid in an overall yield of 15%. 8 was condensed with a terpene synthon (9) unde