A series of prearranged glycosides 5, 17, 23, 28, 37, and 41, having a benzyl-protected 1-thiomannosyl donor linked through its positions 2, 3, 4, and 6 via succinate and malonate tethers, respectively, to positions 2, 3, and 6 of a benzyl glucopyranoside acceptor, were prepared by condensation of t
Synthesis of β-Mannosides via Prearranged Glycosides
✍ Scribed by Thomas Ziegler; Gregor Lemanski
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 120 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0044-8249
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A series of prearranged glycosides 4, 9, 14, 16, 22, 28, 33, 41, and 46, having a benzyl-protected 1thiomannosyl donor linked through its position 6 via malonate and succinate tethers to various positions of glucosamine, galactose, mannose, and rhamnose acceptors, were prepared and cyclized to the c
Engineering enzymes: The glutamic acid nucleophile of a retaining β-mannosidase has been replaced with a serine residue to form a β-mannosynthase. When the new enzyme is provided with an α-mannosyl fluoride donor and an appropriate acceptor, β-mannoside linkages are synthesized. Remarkably, α-mannos