Ether 8 as well as the subsequent THP ethers are mixtures of diastereoisomers.
Synthesis of Verrucarin A and 3α-Hydroxyverrucarin A from Verrucarol and Diacetoxyscripenol (Anguidine). 39th Communication on Verrucarins and Roridins
✍ Scribed by Peter Mohr; Motoo Tori; Peter Grossen; Peter Herold; Christoph Tamm
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- German
- Weight
- 311 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
The title compounds have been synthesized starting from verrucarol and diacetoxyscripenol (anguidine), (E, Z)‐muconic half ester and a derivative of verrucarinic acid. The latter has been prepared in optically active form from dimethyl 3‐methylglutarate.
📜 SIMILAR VOLUMES
The compound should correctly be named apotrichothec-9-ene-3a, 13-diol, because apotrichothecane is the generic name for the skeleton [4]. We thank Dr. Ruegger, Specfrospin, Fallanden and Prof. H . Fritz, Ciba-Geipy AG, Basel, for recording the spectra and the helpful discussion.
## Abstract The macrocyclic trichothecene triester 3′‐hydroxy‐2′‐deoxy‐2",3",4",5"‐tetrahydroverrucarin **A** (**37**), has been synthesized starting from the sesquiterpene alcohol verrucarol (**3**), adipic acid and a derivative of mevalonic acid (**14**). The latter has been prepared from 4‐(tetr