Synthesis of unsymmetric cyclic urea diols, a novel class of HIV protease inhibitors

✍ Scribed by Benjamin R.P. Stone; Gregory D. Harris; Reginald O. Cann; Thomas E. Smyser; Pat N. Confalone

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 200 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01263-5

✦ Synopsis

Unsymmetric cyclic urea diols of general structure 1 can be prepared either via an isourea derived from the symmetric diamine 2 or by the selective removal of a benzyl group from certain symmetric cyclic ureas 8, employing dissolving metal reduction.