A practical synthesis of nonpeptide cyclic ureas as potent HIV protease inhibitors
โ Scribed by Lucius T. Rossano; Young S. Lo; Luigi Anzalone; Ying-Chi Lee; David J. Meloni; James R. Moore; Timothy M. Gale; John F. Arnett
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 168 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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A series of benzofused heterocycles was examined to replace the metabolically unstable benzyl alcohol P2/P2' groups of DMP 323 (1). Extremely potent inhibitors of HIV protease (Ki < 0.01 nM) and excellent antiviral activity (ICgo = 8 nM) were found. An X-ray crystal structure of benzimidazolone 5a b
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