Synthesis of 7-membered cyclic oxamides: Novel HIV-1 protease inhibitors
β Scribed by Prabhakar K Jadhav; Hon-Wah Man
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 205 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Based on the concept of bioisosterism, we report the computer design and the synthesis of original 7-membered ct-phenylthio cyclic oxamides with potent anti HIV-1 properties.
The design and synthesis of potential steroidal HIV-1 protease inhibitors is described. Compounds derived from 11-amino-12-keto-cholanic acid derivatives show modest activity.
Unsymmetric cyclic urea diols of general structure 1 can be prepared either via an isourea derived from the symmetric diamine 2 or by the selective removal of a benzyl group from certain symmetric cyclic ureas 8, employing dissolving metal reduction.