Synthesis of Tritium-labelled Tyrosine, 3 : 5-Diiodotyrosine and Thyroxine
✍ Scribed by TATA, J. R.; BROWNSTONE, A. D.
- Book ID
- 118673842
- Publisher
- Nature Publishing Group
- Year
- 1960
- Tongue
- English
- Weight
- 271 KB
- Volume
- 185
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/185034a0
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📜 SIMILAR VOLUMES
## Abstract The synthesis of a specifically ring labelled isotopomer of L‐tyrosine, (L‐Tyr), using a combination of chemical and enzymatic methods is reported. The tritium labelled [2′,6′]‐L‐Tyr has been synthesized __via__ catalytic exchange of phenol with tritiated water in the presence of K~2~Pt
## Abstract New approaches to the synthesis of 3′‐azido‐3′‐deoxythymidine labelled with tritium in the heterocyclic base have been developed. With this aim, enzymatic transribosylation with [^3^H]thymine using the enzyme preparation from rat liver and a three‐step chemical synthesis with use of the
Two amino acids, 1-BOC-0-ethyl-P-tyrosine and 1-BOC-phenylalanine, have been synthesized in tritium labeled form via exchange with tritium gas over catalyst on an unlabeled precursor and dehydrohalogenation on an iodinated precursor respectively. The tyrosine derivative has been obtained in specifi