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Synthesis of tritium labelled DSP 4, a selective noradrenaline neurotoxin

✍ Scribed by Christer Sahlberg; Lars Gawell

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
160 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

DSP 4 (N-( 2-Chl oroethyl 1 -N-ethyl -2-bromobenzyl ami ne, 1) i s a neurotoxin, selective f o r neuronal noradrenaline (NAI. Tritium l a b e l l e d DSP 4 (Q) w i t h a specific a c t i v i t y o f 105 m C i / m l was prepared. The key step i n the synthesis i s a reduction o f the m i n o e s t e r ? with a c t iv i tated sodium boro [ 3H jhydri de thus forming the a1 coho1 9.

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