Synthesis of tritium labelled (−)-3-PPP, a selective dopamine autoreceptor agonist
✍ Scribed by Seth-Olov Thorberg; Lars Johansson; Lars Gawell; Christer Sahlberg
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- French
- Weight
- 282 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-2135
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DSP 4 (N-( 2-Chl oroethyl 1 -N-ethyl -2-bromobenzyl ami ne, 1) i s a neurotoxin, selective f o r neuronal noradrenaline (NAI. Tritium l a b e l l e d DSP 4 (Q) w i t h a specific a c t i v i t y o f 105 m C i / m l was prepared. The key step i n the synthesis i s a reduction o f the m i n o e s t e
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## Conclusions The synthesis of AZD4619 included 14 steps with an overall yield of 13%. To reach the requirements of an increase in molecular weight by at least nine, both 13 C and 2 H had to be incorporated. According to our previous experiences the loss of deuterium in acidic positions necessita