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Synthesis of 13C- and 2H-labelled AZD4619: a selective PPARα agonist

✍ Scribed by Karin Wiklund; Göran N. Nilsson

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
84 KB
Volume
50
Category
Article
ISSN
0022-2135

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✦ Synopsis

Conclusions

The synthesis of AZD4619 included 14 steps with an overall yield of 13%. To reach the requirements of an increase in molecular weight by at least nine, both 13 C and 2 H had to be incorporated. According to our previous experiences the loss of deuterium in acidic positions necessitates the use of deuterated solvents and reagents.

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