Synthesis of a tritium-labelled diether analog of phosphatidylinositol 4,5-bisphosphate
โ Scribed by Jian Chen; Glenn D. Prestwich
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- French
- Weight
- 413 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-2135
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The synthesis of the title compound labelled with tritium in the proline residue is reported. A five-step sequence starting f?om the commercially available fH]proline 1 afforded fHJTHF-y2 with a radiochemical purity 297Y0 and a high specific activity (>3.7 TBqlmmol). The overall radiochemical yield
A tritium labelled phospholipase A2 (PLA2) amide analogue inhibitor was prepared by the reduction of an alkene precursor. Diimide, heterogeneous and homogeneous metal catalyzed reduction methods were assessed for their suitability for the preparation of a tritiated ligand for 3H NMR spectroscopic st
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