Synthesis of a tritium labelled analog of the novel hematoregulatory agent SB 209978
โ Scribed by Dirk Heerding; David Saunders
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- French
- Weight
- 284 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The tritium labeled form of 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo[4,3-e] 1,2,4-triazolo[l,5-c]pyrimidine (3H-SCH 58261) was obtained by reduction of 5-amino-7-[2-(2',4',5'-tribromo)phenylethyl]-2-(2-furyl)-pyrazolo[4,3-e] 1,2,4-triazolo[ 1,5clpyrimidine with tritium gas in the presence of 10
We describe herein the synthesis of polybromodiphenylacetic acid (&), a fragment common to the tritiation substrates (a) and (JJ) of the sodium channel blocker, PD-85639 (1) and the angiotensin II inhibitor EXP-655 (2) respectively. Preparation of (a) and (11) followed by reductive debromonation wit