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Synthesis of tritiated (S)-10-bromoacetamidomethylcamptothecin

✍ Scribed by Arthur Y. L. Shu; Dalia Jakas; J. Richard Heys

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
379 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Tritiated (S)‐10‐bromoacetamidomethylcamptothecin was prepared starting from (S)‐10‐hydroxycamptothecin. The key step consisted of palladium catalyzed direct tritium exchange on the intermediate (S)‐10‐aminomethylcamptothecin. ^3^H NMR spectroscopy indicated the tritium label was located exclusively at the C‐5 position.

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