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Synthesis of tritiated bumetanide

✍ Scribed by Steven D. Wyrick; Susan Morris-Natschke; Peter K. Lauf

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
308 KB
Volume
21
Category
Article
ISSN
0022-2135

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✦ Synopsis

Summarv

Tritium lahelled bumetanide of high specific activity (16 Ci/mmol) has been prepared in our lahoratory by tris(tripheny1phosphine) rhodium chloride catalyzed reduction of an olefinic precursor with carrier free tritium pas in benzene-ethanol (1:l). The product is labelled in the N-butyl side chain. Comparison of both heterogeneous palladium and homogeneous rhodium catalyzed deuterium reductions as a model for the tritiation revealed that the latter reduction was accompanied by considerably less label scrambling.

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