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Synthesis of tritiated cromolyn diethyl ester

✍ Scribed by Steven D. Wyrick; V. Ranga

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
293 KB
Volume
21
Category
Article
ISSN
0022-2135

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✦ Synopsis

W e r e p o r t here the s y n t h e s i s of t r i t i a t e d cromolyn d i e t h y l e s t e r of high s p e c i f i c a c t i v i t y and acceptable s t a b i l i t y f o r use i n i n v i t r o and i n vivo models of experimental asthma i n the guinea pig. a t e d precursor, 1,3-bis-(2-acetyl-3-hydroxy -6-bromophenoxy)-2-propanol, followed by c a t a l y t i c debromination with tritium gas and two subsequent synthet i c s t e p s atforded t r i t i a t e d cromolyn d i e t h y l e s t e r with a s p e c i f i c a c t i v i t y of 135 mCi/mg (71 Ci/nrmol).

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