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Synthesis of Trifluoromethylated Amines Using 1,1-Bis(dimethylamino)-2,2,2-trifluoroethane

โœ Scribed by Xu, Yuelian; Dolbier, William R.


Book ID
127378540
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
129 KB
Volume
65
Category
Article
ISSN
0022-3263

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Facile synthesis of trifluoromethyl carb
โœ Yuelian Xu; William R. Dolbier Jr. ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 207 KB

1,1-Bis(dimethylamino)-2,2,2-trifluoroethane is an excellent synthetic building-block replacement for trifluoroacetaldehyde in condensation reactions with ketones using 36% aqueous HCI catalysis. Moderate to good yields (43-68%) of trifluoromethyl carbinols are obtained with symmetric and unsymmetri