1,1-Bis(dimethylamino)-2,2,2-trifluoroethane, a Readily-Available Precursor to the Novel Fluorinated Building Block 1,1-Bis(dimethylamino)-2,2-difluoroethene
β Scribed by Xu, Yuelian; Dolbier,, William R.; Rong, Xiao X.
- Book ID
- 121420195
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 167 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
1,1-Bis(dimethylamino)-2,2,2-trifluoroethane is an excellent synthetic building-block replacement for trifluoroacetaldehyde in condensation reactions with ketones using 36% aqueous HCI catalysis. Moderate to good yields (43-68%) of trifluoromethyl carbinols are obtained with symmetric and unsymmetri
## Abstract The title compound **4** is generated from the phosphoric amide **5** in tetrahydrofuran with butyllithium. The lithium reagent **4** is stable at room temperature; its reactions with electrophiles furnish the products **6β22**, **26**, **27**, see __Table 1__ and the __Scheme__. A seco