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Synthesis of Tricyclic Analogues of Stephaoxocanidine and Their Evaluation as Acetylcholinesterase Inhibitors.

✍ Scribed by Dario A. Bianchi; Guillermo Schmeda Hirschmann; Cristina Theoduloz; Andrea B. J. Bracca; Teodoro S. Kaufman

Publisher
John Wiley and Sons
Year
2005
Weight
17 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Abstract The synthesis of tacrine‐thiadiazolidinone hybrids is described. These compounds are designed as dual acetylcholinesterase inhibitors binding simultaneously to the peripheral and catalytic sites of the enzyme. All tested compounds exhibit significant AChE inhibitory activity. Competitio