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Synthesis and Biological Evaluation of Functionalized Coumarins as Acetylcholinesterase Inhibitors.

✍ Scribed by Qiong Shen; Quan Peng; Jialiang Shao; Xufeng Liu; Zhishu Huang; Xianzhang Pu; Lin Ma; Yue-Ming Li; Albert S. C. Chan; Lianquan Gu


Publisher
John Wiley and Sons
Year
2006
Weight
32 KB
Volume
37
Category
Article
ISSN
0931-7597

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Synthesis and Biological Evaluation of T
✍ Isabel Dorronsoro; Diana Alonso; Ana Castro; Maria del Monte; Esther GarcΓ­a-Palo πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 125 KB πŸ‘ 2 views

## Abstract The synthesis of tacrine‐thiadiazolidinone hybrids is described. These compounds are designed as dual acetylcholinesterase inhibitors binding simultaneously to the peripheral and catalytic sites of the enzyme. All tested compounds exhibit significant AChE inhibitory activity. Competitio