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Synthesis and Biological Evaluation of Tacrine-Thiadiazolidinone Hybrids as Dual Acetylcholinesterase Inhibitors.

✍ Scribed by Isabel Dorronsoro; Diana Alonso; Ana Castro; Maria del Monte; Esther Garcia-Palomero; Ana Martinez


Publisher
John Wiley and Sons
Year
2005
Weight
17 KB
Volume
36
Category
Article
ISSN
0931-7597

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Synthesis and Biological Evaluation of T
✍ Isabel Dorronsoro; Diana Alonso; Ana Castro; Maria del Monte; Esther GarcΓ­a-Palo πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 125 KB πŸ‘ 2 views

## Abstract The synthesis of tacrine‐thiadiazolidinone hybrids is described. These compounds are designed as dual acetylcholinesterase inhibitors binding simultaneously to the peripheral and catalytic sites of the enzyme. All tested compounds exhibit significant AChE inhibitory activity. Competitio