Synthesis and Biological Evaluation of T
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Isabel Dorronsoro; Diana Alonso; Ana Castro; Maria del Monte; Esther GarcΓa-Palo
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Article
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2005
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John Wiley and Sons
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English
β 125 KB
π 2 views
## Abstract The synthesis of tacrineβthiadiazolidinone hybrids is described. These compounds are designed as dual acetylcholinesterase inhibitors binding simultaneously to the peripheral and catalytic sites of the enzyme. All tested compounds exhibit significant AChE inhibitory activity. Competitio