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Synthesis and Evaluation of Tacrine-E2020 Hybrids as Acetylcholinesterase Inhibitors for the Treatment of Alzheimer′s Disease.

✍ Scribed by Dong Shao; Chunyan Zou; Cheng Luo; Xican Tang; Yuanchao Li


Publisher
John Wiley and Sons
Year
2004
Weight
12 KB
Volume
35
Category
Article
ISSN
0931-7597

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✍ Isabel Dorronsoro; Diana Alonso; Ana Castro; Maria del Monte; Esther García-Palo 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB 👁 2 views

## Abstract The synthesis of tacrine‐thiadiazolidinone hybrids is described. These compounds are designed as dual acetylcholinesterase inhibitors binding simultaneously to the peripheral and catalytic sites of the enzyme. All tested compounds exhibit significant AChE inhibitory activity. Competitio