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Synthesis of the Streptomyces ambofaciens antineoplastic constituent 6-diazo-5-oxo-L-norleucine

✍ Scribed by Pettit, George R.; Nelson, Paul S.

Book ID
120287863
Publisher
American Chemical Society
Year
1983
Tongue
English
Weight
627 KB
Volume
48
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES

The inhibition by 6-diazo-5-oxo-L-norleu
The inhibition by 6-diazo-5-oxo-L-norleucine of glutamine catabolism of the cultured human lymphoblast
✍ Randall C. Willis; J. Edwin Seegmiller πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 English βš– 883 KB

## Abstract The rapid catabolism of glutamine by the cultured human lymphoblast line WI‐L2 can be inhibited greater than 95% by incubation of cell suspensions with 6‐diazo‐5‐oxo‐L‐norleucine (DON). The inhibition persists for at least four hours after removal of DON from the cell suspension. The ex