Inhibition of replication of human respiratory syncytial virus by 6-diazo-5-oxo-l-norleucine
β Scribed by Robert C. Huang; Milita Panin; Rita R. Romito; Yung T. Huang
- Book ID
- 118393343
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 854 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0166-3542
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## Abstract The rapid catabolism of glutamine by the cultured human lymphoblast line WIβL2 can be inhibited greater than 95% by incubation of cell suspensions with 6βdiazoβ5βoxoβLβnorleucine (DON). The inhibition persists for at least four hours after removal of DON from the cell suspension. The ex
The effects of 6-diazo-5-oxo-L-norleucine (DON), 2-deoxy-D-glucose (DOG), and tunicamycin (TM) on the replication of poliovirus (PV) and vesicular stomatitis virus (VSV) were examined. During a 48-hr replication period, TM, DON, and DOG inhibit VSV plaque formation in HEp-2 cells by 99.9%, 99.8%, an
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v