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Inactivation of glutamin-(asparagin)-ase fromPseudomonas aurantiaca548 by azaserine and 6-diazo-5-oxo-L-norleucine

✍ Scribed by Z. I. Lebedeva; E. A. Kabanova; T. T. Berezov


Book ID
104965085
Publisher
Springer US
Year
1985
Tongue
English
Weight
212 KB
Volume
100
Category
Article
ISSN
0007-4888

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The inhibition by 6-diazo-5-oxo-L-norleu
✍ Randall C. Willis; J. Edwin Seegmiller πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 English βš– 883 KB

## Abstract The rapid catabolism of glutamine by the cultured human lymphoblast line WI‐L2 can be inhibited greater than 95% by incubation of cell suspensions with 6‐diazo‐5‐oxo‐L‐norleucine (DON). The inhibition persists for at least four hours after removal of DON from the cell suspension. The ex