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Comparison of the hydrolysis and the covalent binding of 6-diazo-5-oxo-l-[6-14C]norleucine by rat renal phosphate-dependent glutaminase

✍ Scribed by Virginia M. Clark; Richard A. Shapiro; Norman P. Curthoys


Book ID
115705387
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
1017 KB
Volume
213
Category
Article
ISSN
0003-9861

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The inhibition by 6-diazo-5-oxo-L-norleu
✍ Randall C. Willis; J. Edwin Seegmiller 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 883 KB

## Abstract The rapid catabolism of glutamine by the cultured human lymphoblast line WI‐L2 can be inhibited greater than 95% by incubation of cell suspensions with 6‐diazo‐5‐oxo‐L‐norleucine (DON). The inhibition persists for at least four hours after removal of DON from the cell suspension. The ex