𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacokinetic and phase I study of intravenous DON (6-diazo-5-oxo-L-norleucine) in children

✍ Scribed by Margaret P. Sullivan; J. Arly Nelson; Stuart Feldman; Bay Nguyen


Book ID
104690023
Publisher
Springer
Year
1988
Tongue
English
Weight
634 KB
Volume
21
Category
Article
ISSN
0344-5704

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Uptake of glutamine antimetabolites 6-di
✍ Klaus R. Huber; Henry Rosenfeld; Joseph Roberts πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 French βš– 488 KB

The uptake system for 6-diazo-5-0x0-L-norleucine (DON) was studied in mouse P388 leukemia cells. The D O N transport system was found to resemble that of another glutamine antimetabolite, Acivicin, in its strong temperature dependence, utilization of the "L" transport system, inhibition by glutamine

Phase II trial of 6-diazo-5-oxo-L-norleu
✍ Robert H. Earhart; David J. Amato; Alex Yuang-Chi Chang; Ernest C. Borden; Masan πŸ“‚ Article πŸ“… 1990 πŸ› Springer US 🌐 English βš– 539 KB

Ninety-eight patients with previously-treated advanced soft tissue sarcoma, bone sarcoma, or mesothelioma were randomly assigned to one of two intravenous single-agent treatment regimens, either 6-diazo-5-oxo-l-norleucine (DON; brief infusions of 50 mg/m2/day for 5 consecutive days every 4 weeks) or