Pharmacokinetic and phase I study of intravenous DON (6-diazo-5-oxo-L-norleucine) in children
β Scribed by Margaret P. Sullivan; J. Arly Nelson; Stuart Feldman; Bay Nguyen
- Book ID
- 104690023
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 634 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The uptake system for 6-diazo-5-0x0-L-norleucine (DON) was studied in mouse P388 leukemia cells. The D O N transport system was found to resemble that of another glutamine antimetabolite, Acivicin, in its strong temperature dependence, utilization of the "L" transport system, inhibition by glutamine
Ninety-eight patients with previously-treated advanced soft tissue sarcoma, bone sarcoma, or mesothelioma were randomly assigned to one of two intravenous single-agent treatment regimens, either 6-diazo-5-oxo-l-norleucine (DON; brief infusions of 50 mg/m2/day for 5 consecutive days every 4 weeks) or