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Synthesis of the pentacyclic xestobergsterol skeleton

โœ Scribed by Marie E. Krafft; Olivier A. Dasse; Bin Shao


Book ID
108379002
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
710 KB
Volume
54
Category
Article
ISSN
0040-4020

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๐Ÿ“œ SIMILAR VOLUMES


ChemInform Abstract: Synthesis of the Pe
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Synthesis of the Pentacyclic Xestobergsterol Skeleton. -The key steps in the synthesis of the pentacyclic skeleton (X) are stereoselective formation of the ynol (VII) and intramolecular Pauson-Khand reaction of the enyne (VIII). Xestobergsterol is a histamine release inhibitor. -(KRAFFT,

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Synthesis of 7-Deoxyxestobergsterol A, a Novel Pentacyclic Steroid of the Xestobergsterol Class. -Starting from stigmasterol the known alcohol (I) is obtained. An efficient route that utilizes the Breslow remote functionalization process gives the title steroid (VIII). To determine this strategy es