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ChemInform Abstract: Synthesis of 7-Deoxyxestobergsterol A, a Novel Pentacyclic Steroid of the Xestobergsterol Class.

โœ Scribed by M. E. JUNG; T. W. JOHNSON

Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
29
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Synthesis of 7-Deoxyxestobergsterol A, a Novel Pentacyclic Steroid of the Xestobergsterol Class.

-Starting from stigmasterol the known alcohol (I) is obtained. An efficient route that utilizes the Breslow remote functionalization process gives the title steroid (VIII). To determine this strategy especially for the final production of the cis C/D ring junction molecular mechanics calculations are carried out on tricyclic model systems. -(JUNG,

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ChemInform Abstract: Synthesis of the Pe
ChemInform Abstract: Synthesis of the Pentacyclic Xestobergsterol Skeleton.
โœ M. E. KRAFFT; O. A. DASSE; B. SHAO ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 34 KB ๐Ÿ‘ 2 views

Synthesis of the Pentacyclic Xestobergsterol Skeleton. -The key steps in the synthesis of the pentacyclic skeleton (X) are stereoselective formation of the ynol (VII) and intramolecular Pauson-Khand reaction of the enyne (VIII). Xestobergsterol is a histamine release inhibitor. -(KRAFFT,