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ChemInform Abstract: Synthesis of the Pentacyclic Xestobergsterol Skeleton.

โœ Scribed by M. E. KRAFFT; O. A. DASSE; B. SHAO

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
29
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Synthesis of the Pentacyclic Xestobergsterol Skeleton.

-The key steps in the synthesis of the pentacyclic skeleton (X) are stereoselective formation of the ynol (VII) and intramolecular Pauson-Khand reaction of the enyne (VIII). Xestobergsterol is a histamine release inhibitor. -(KRAFFT,

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ChemInform Abstract: Synthesis of 7-Deoxyxestobergsterol A, a Novel Pentacyclic Steroid of the Xestobergsterol Class.
โœ M. E. JUNG; T. W. JOHNSON ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 35 KB

Synthesis of 7-Deoxyxestobergsterol A, a Novel Pentacyclic Steroid of the Xestobergsterol Class. -Starting from stigmasterol the known alcohol (I) is obtained. An efficient route that utilizes the Breslow remote functionalization process gives the title steroid (VIII). To determine this strategy es