ChemInform Abstract: First Total Synthesis of Xestobergsterol A and Active Structural Analogues of the Xestobergsterols.
β Scribed by Michael E. Jung; Ted W. Johnson
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 25 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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Synthesis of 7-Deoxyxestobergsterol A, a Novel Pentacyclic Steroid of the Xestobergsterol Class. -Starting from stigmasterol the known alcohol (I) is obtained. An efficient route that utilizes the Breslow remote functionalization process gives the title steroid (VIII). To determine this strategy es
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Synthesis of the Pentacyclic Xestobergsterol Skeleton. -The key steps in the synthesis of the pentacyclic skeleton (X) are stereoselective formation of the ynol (VII) and intramolecular Pauson-Khand reaction of the enyne (VIII). Xestobergsterol is a histamine release inhibitor. -(KRAFFT,