ChemInform Abstract: A Novel Class of Inhibitors for Steroid 5α-Reductase: Synthesis and Evaluation of Umbelliferone Derivatives.
✍ Scribed by Gao-jun Fan; Woongchon Mar; Man Ki Park; Eun Wook Choi; Kinam Kim; Sanghee Kim
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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Pyrrolebutyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase. -A series of pyrrolebutyric acid derivatives (I) (37 examples) are synthesized and evaluated for their inhibitory activity on steroid 5α-reductase in vitro and ex vivo. The calcium salt of (Id) shows potent inhibitory activities