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ChemInform Abstract: Pyrrolebutyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase.

✍ Scribed by M. KATO; K. KOMODA; A. NAMERA; Y. SAKAI; S. OKADA; A. YAMADA; K. YOKOYAMA; E. MIGITA; Y. MINOBE; T. TANI

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Pyrrolebutyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase.

-A series of pyrrolebutyric acid derivatives (I) (37 examples) are synthesized and evaluated for their inhibitory activity on steroid 5α-reductase in vitro and ex vivo. The calcium salt of (Id) shows potent inhibitory activities against both rat and human 5α-reductase. -(KATO, M.

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