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ChemInform Abstract: A Novel Class of Inhibitors for Human Steroid 5α-Reductase: Phenoxybenzoic Acid Derivatives. Part 1.

✍ Scribed by Susumu Igarashi; Takenori Kimura; Ryo Naito; Hiromu Hara; Masahiro Fuji; Hiroshi Koutoku; Hiroyuki Oritani; Toshiyasu Mase

Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
31
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Pyrrolebutyric Acid
ChemInform Abstract: Pyrrolebutyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase.
✍ M. KATO; K. KOMODA; A. NAMERA; Y. SAKAI; S. OKADA; A. YAMADA; K. YOKOYAMA; E. MI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB

Pyrrolebutyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase. -A series of pyrrolebutyric acid derivatives (I) (37 examples) are synthesized and evaluated for their inhibitory activity on steroid 5α-reductase in vitro and ex vivo. The calcium salt of (Id) shows potent inhibitory activities