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Synthesis of the optically active key intermediate of FR901483

โœ Scribed by Shigeru Ieda; Toshiyuki Kan; Tohru Fukuyama

Book ID
104097877
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
454 KB
Volume
51
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Efficient synthesis of the tricyclic key intermediate 2 for (ร€)-FR901483 1 was accomplished. The precursor of the intramolecular aldol reaction 4b is constructed by the Ugi 4CC reaction and subsequent intramolecular Dieckmann condensation. This approach allows a fully stereocontrolled total synthesis of (ร€)-FR901483, which would provide various derivatives.

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