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Preparation of an optically active intermediate for the synthesis of prostaglandins

✍ Scribed by Corey, E. J.; Snider, Barry B.


Book ID
127380840
Publisher
American Chemical Society
Year
1974
Tongue
English
Weight
467 KB
Volume
39
Category
Article
ISSN
0022-3263

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Synthesis of the optically active key in
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Efficient synthesis of the tricyclic key intermediate 2 for (Γ€)-FR901483 1 was accomplished. The precursor of the intramolecular aldol reaction 4b is constructed by the Ugi 4CC reaction and subsequent intramolecular Dieckmann condensation. This approach allows a fully stereocontrolled total synthesi