𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of the northern hemisphere of the milbemycins using a new strategy for the formation of the C15 to C16 bond.

✍ Scribed by David Culshaw; Peter Grice; Steven V. Ley; Gary A. Strange

Book ID
104229092
Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
143 KB
Volume
26
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Using a new convergent route the synthesis of the C-11 to C-25 northern hemisphere fragment of the milbemycins has been achieved.

📜 SIMILAR VOLUMES

Strategy for the synthesis of the C10C1
Strategy for the synthesis of the C10C19 portion of amphidinoide-A
✍ Stephen J. O'Connor; Paul G. Williard 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 255 KB

A stereospecific synthesis of a potential Cl&Cl9 fragment of the novel antineoplastic macrolide amphidinolide-A is described. ## Amphidinolide-A (1) was isolated from dinoflagellate Amphidinium sp. by Kobayashi et. all. This compound has shown in v&-u activity against L1210 (I&j0 2.4 ng/mL) murin

Photooxygenation of the CN bond: a mild
Photooxygenation of the CN bond: a mild new method for oxidative CC cleavage
✍ Nüket Öcal; Lovelle M. Yano; Ihsan Erden 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 132 KB

Upon photooxygenation in the presence of base, a-oximinocarbonyl compounds undergo clean oxidative C C cleavage giving rise to mixtures of esters and acids. The mechanism of these reactions involves some unusual peroxidic intermediates, including a 2,3,5-trioxapentanes.

Addition of carbon radicals to 4′,5′-uns
Addition of carbon radicals to 4′,5′-unsaturated uracilnucleosides by the use of organoselenium reagents: A new stereoselective entry to CC bond formation at the 5′-position
✍ Kazuhiro Haraguchi; Hiromichi Tanaka; Tadashi Miyasaka 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 262 KB

Addition of carbon radicals generated from organoselenium reagents P SeR: R= COPh, CO\*Et, CH,CO,Et, CH2COMe, and CH,CN) to 4',5'-unsaturated uraciinucleosides was found to provide a highly efficient entry to C-C bond formation at the 5'-position, the stereochemical outcome of which is dependent upo

Studies in marine macrolide synthesis: S
Studies in marine macrolide synthesis: Synthesis of the C1C15 subunit of spongistatin 1 (altohyrtin A) and 15,16-anti aldol coupling reactions
✍ Ian Paterson; Renata M. Oballa 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 260 KB

The CI-C15 aldehyde 3, containing the AB-spiroacetal of spongistatin 1 (1), was prepared in 17 steps from methyl ketone (S)-8. The C15 and CI6 stereocentres could be introduced together, relying on Felkin-Anh control, by using a boron-mediated, anti aldol coupling reaction, as in 22 ~ 25 and 26.