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Addition of carbon radicals to 4′,5′-unsaturated uracilnucleosides by the use of organoselenium reagents: A new stereoselective entry to CC bond formation at the 5′-position

✍ Scribed by Kazuhiro Haraguchi; Hiromichi Tanaka; Tadashi Miyasaka

Publisher: Elsevier Science
Year: 1990
Tongue: French
Weight: 262 KB
Volume: 31
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)94378-8

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✦ Synopsis

Addition of carbon radicals generated from organoselenium reagents P SeR: R= COPh, CO*Et, CH,CO,Et, CH2COMe, and CH,CN) to 4',5'-unsaturated uraciinucleosides was found to provide a highly efficient entry to C-C bond formation at the 5'-position, the stereochemical outcome of which is dependent upon the hydroxyl protecting group.