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Strategy for the synthesis of the C10C19 portion of amphidinoide-A

✍ Scribed by Stephen J. O'Connor; Paul G. Williard

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
255 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

A stereospecific synthesis of a potential Cl&Cl9 fragment of the novel antineoplastic macrolide amphidinolide-A is described.

Amphidinolide-A

(1) was isolated from dinoflagellate Amphidinium sp. by Kobayashi et. all. This compound has shown in v&-u activity against L1210 (I&j0 2.4 ng/mL) murine leukemia cells2 Compound 1, although structurally similar to swineholide A3a and scytophycin B,3b possesses some unusual features. For

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