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A short and efficient synthesis of the C-3 to C-10 portion of the maytansinoids

✍ Scribed by David M. Hodgson; Philip J. Parsons; Peter A. Stones

Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 829 KB
Volume: 47
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)86450-4

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✦ Synopsis

The cyclic carbamate (3), a key intermediate in our projected synthesis of trenudine (2), has been synthesised from 3,4-epoxycyclohexene (4) by ozonolytic cleavage of the cyclopentene (9) as a key step.

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