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Efficient route to the synthesis of C-2, C-3 substituted 4-piperidones

✍ Scribed by Dharmpal S. Dodd; Allan C. Oehlschlager

Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 209 KB
Volume: 32
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)79755-3

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✦ Synopsis

l-Carbobenzoxy-3-carbomethoxy-5,6-dihydro-4-pyridone (I) has proven to be exceptionally receptive in the conjugate addition of organocuprates to give C-2 substituted piperidones having the C-3 position activated toward alkylation.

Enone 1 was used as the key synthon in the synthesis of C-l, C-2 and C-3 substituted 4-piperidinol (8).

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