A new route to heterocyclic compounds by the mercuric acetate oxidation of N-alkyl substituted 4-piperidones

✍ Scribed by Andrew C. Flick; Albert Padwa

• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 185 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.07.109

✦ Synopsis

N-Alkyl substituted 4-piperidones readily undergo oxidation in high yield upon reaction with mercuric acetate. Application of the oxidation to the synthesis of the skeletal framework of several alkaloids is described.