Paroxetine is a well-known antidepressant, used worldwide in therapeutics. In comparison with other selective serotonin reuptake inhibitors, it exhibits the highest activity in serotonin reuptake inhibition. Paroxetine metabolism initially involves its demethylenation to the catechol intermediate, w
Synthesis of the major metabolites of Tolvaptan
โ Scribed by Wan, Wei Li; Wu, Jian Bo; Lei, Fan; Li, Xiao Long; Hai, Li; Wu, Yong
- Book ID
- 118428007
- Publisher
- Chinese Electronic Periodical Services
- Year
- 2012
- Tongue
- English
- Weight
- 282 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1001-8417
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The stereospeciยฎc synthesis of 6-a-hydroxy paclitaxel 10, the major human metabolite of paclitaxel, is described. The 6,7-a-diol 4, obtained from paclitaxel, is converted to the 6,7-b-cyclic sulfate followed by nitrate addition and reduction to aord the title compound.
## Abstract Ambroxol is a mucolytic agent used in the treatment of respiratory diseases. Herein, we report the synthesis of carbonโ14โlabeled ambroxol with the radioactive atom(s) either on the benzylic carbon or uniformly in the cyclohexyl ring with specific activities of 59 and 81โmCi/mmol, respe