โ Scribed by Mark D Wittman; John F Kadow; Dolatrai M Vyas
No coin nor oath required. For personal study only.
The stereospeciยฎc synthesis of 6-a-hydroxy paclitaxel 10, the major human metabolite of paclitaxel, is described. The 6,7-a-diol 4, obtained from paclitaxel, is converted to the 6,7-b-cyclic sulfate followed by nitrate addition and reduction to aord the title compound.
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## Abstract This paper describes the synthesis of deuteriumโlabelled paclitaxel and its hydroxyl metabolite. Paclitaxel labelled with ^2^H was obtained in four steps using the commercially available [^2^H~5~]benzoic chloride as the stable labelled reagent with a 40% overall yield. The hydroxyl meta
The stereospecific synthesis of the recently identified metabolites of LT8 1: 5(S),lZ(R),20-trihydroxy-6-cis,8,10-trans,l4-cis-eicosatetraenoic acid 2 and 5(S),12!Rr,dihydroxy-6-cis,8,10-trans,l4-cis-eicosatetraen-l,20-dioic acid 3, via thz synthon 4 has been accomplished; identity of synthetic and
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a โFull Textโ option. The original article is trackable v